Books, Reports, and Theses
Peer-Reviewed Articles
Abstracts
Books, Reports, and Theses
J. F. Holson, Teratogenic Potential of D-Lysergic Acid Diethylamide (delysid) in the Albino Rat. Master’s Thesis, East Carolina University, 1970.
J. F. Holson, Relative Transport Roles of Chorioallantic and Yolk Sac Placentae on the 12th and 13th Days of Gestation. Doctoral Dissertation, University of Cincinnati, 1974.
C. G. White, J. F. Holson, J. F. Young, “Extrapolation models in teratogenesis,” NCTR Final Report for Experiment No. 281. National Center for Toxicological Research, Jefferson, AR, 1981.
C. A. Kimmel, J. F. Holson, C. J. Hogue, G. L. Carlo, “Reliability of experimental studies for predicting hazards to human development,” NCTR Final Report for Experiment No. 6015. National Center for Toxicological Research, Jefferson, AR, 1984.
C. P. Chengelis, J. F. Holson, S. C. Gad, Introduction, in Regulatory Toxicology. Raven Press Ltd, New York, New York, 1995, pp. 1-8.
C. P. Chengelis, J. F. Holson, S. C. Gad, Eds., Regulatory Toxicology. Raven Press Ltd, New York, New York, 1995.
NRC (National Research Council) Committee on Developmental Toxicology (E. M. Faustman, J. C. Gerhart, N. A. Brown, G. P. Daston, M. C. Fishman, J. F. Holson, H. B. W. M. Koëter, A. P. Mahowald, J. M. Manson, R. K. Miller, P. E. Mirkes, D. W. Nebert, D. M. Noden, V. E. Papaioannou, G. C. Schoenwolf, F. Welsch, W. B. Wood), Scientific Frontiers in Developmental Toxicology and Risk Assessment. National Academy Press, Washington, DC, 2000.
NRC (National Research Council) Subcommittee on Reproductive and Developmental Toxicology (C. A. Kimmel, G. M. Buck, M. H. Feuston, P. M. D. Foster, J. M. Friedman, J. F. Holson, C. L. Hughes, J. A. Moore, B. A. Schwetz, A. R. Scialli, W. J. Scott, C. V. Vorhees, B. R. Zirkin), Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity. National Academy Press, Washington, DC, 2001.
M. J. Beck, E. L. Padgett, C. J. Bowman, D. T. Wilson, L. E. Kaufman, B. J. Varsho, D. G. Stump, M. D. Nemec, J. F. Holson, Nonclinical Juvenile Toxicity Testing, Chapter 8, in Developmental and Reproductive Toxicology: A Practical Approach, Second Edition (R. D. Hood, Ed.). Taylor and Francis: Boca Raton, FL, 2006, pp. 263-327.
J. F. Holson, M. D. Nemec, D. G. Stump, L. E. Kaufman, P. Lindstrom, B. J. Varsho, Significance, Reliability, and Interpretation of Developmental and Reproductive Toxicity Study Findings, Chapter 9, in Developmental and Reproductive Toxicology: A Practical Approach, Second Edition (R. D. Hood, Ed.). Taylor and Francis: Boca Raton, FL, 2006, pp. 329-424.
Peer-Reviewed Articles
T. F. X. Collins, D. I. Ruggles, J. F. Holson, H. J. Schumacher, D. W. Gaylor, G. L. Kennedy, Teratological evaluation of FD&C red no. 2—a collaborative government‐industry study. I. Introduction, experimental materials, and procedures. Journal of Toxicology and Environmental Health, Part A Current Issues 1, 851-856 (1976).
J. F. Holson, D. W. Gaylor, H. J. Schumacher, T. F. X. Collins, D. I. Ruggles, M. L. Keplinger, G. L. Kennedy, Teratological evaluation of FD&C red no. 2—a collaborative government‐industry study. V. Combined findings and discussion. Journal of Toxicology and Environmental Health, Part A Current Issues 1, 875-885 (1976).
J. F. Holson, H. J. Schumacher, D. W. Gaylor, T. B. Gaines, T. F. X. Collins, Teratological evaluation of FD&C red no. 2—a collaborative government‐industry study. IV. NCTR’s study. Journal of Toxicology and Environmental Health, Part A Current Issues 1, 867-874 (1976).
W. J. Scott, J. F. Holson, Weight differences in rat embryos prior to sexual differentiation. Journal of Embryology and Experimental Morphology 40, 259-263 (1977).
J. Buelke-Sam, J. F. Holson, J. J. Bazare, J. F. Young, Comparative stability of physiological parameters during sustained anesthesia in rats. Laboratory Animal Science 28, 157-162 (1978).
C. J. Nelson, J. F. Holson, Statistical analysis of teratologic data: problems and advancements. Journal of Environmental Pathology and Toxicology 2, 187-199 (1978).
J. F. Young, J. F. Holson, Utility of pharmacokinetics in designing toxicological protocols and improving interspecies extrapolation. Journal of Environmental Pathology and Toxicology 2, 169-186 (1978).
H. G. Green, C. J. Nelson, D. W. Gaylor, J. F. Holson, Accuracy of birth certificate data for detecting facial cleft defects in Arkansas children. Cleft Palate Journal 16, 167-170 (1979).
J. B. LaBorde, D. L. Tullis, J. F. Young, J. F. Holson, Measurement of protein in serum and rodent embryos by spectrophotometry at 215 and 225 nm. Microchemical Journal 24, 275-286 (1979).
C. J. Nelson, J. F. Holson, H. G. Green, D. W. Gaylor, Retrospective study of the relationship between agricultural use of 2, 4, 5‐T and cleft palate occurrence in Arkansas. Teratology 19, 377-383 (1979).
D. M. Sheehan, J. F. Holson, Threatened abortion, hormone therapy, and malformed embryos: a comment. Teratology 22, 351-352 (1980).
R. A. Byrd, C. A. Kimmel, M. D. Morris, J. F. Holson, J. F. Young, Altered pattern of prenatal toxicity in rats due to different treatment schedules with mirex. Toxicology and Applied Pharmacology 60, 213-219 (1981).
J. F. Holson, C. A. Kimmel, C. J. Hogue, G. L. Carlo, Suitability of experimental studies for predicting hazards to human development: criteria for evaluation of study designs. Proceedings of the 1981 Annual Winter Meeting of the Toxicology Forum (1981), pp. 354-390.
J. T. McVey, J. Hunziker, J. F. Holson, J. F. Young, Small animal traversing gamma counter. Journal of Pharmacological Methods 5, 1-13 (1981).
J. Buelke‐Sam, J. F. Holson, C. J. Nelson, Blood flow during pregnancy in the rat: II. Dynamics of and litter variability in uterine flow. Teratology 26, 279-288 (1982).
J. Buelke‐Sam, C. J. Nelson, R. A. Byrd, J. F. Holson, Blood flow during pregnancy in the rat: I. Flow patterns to maternal organs. Teratology 26, 269-277 (1982).
R. A. Byrd, J. F. Young, C. A. Kimmel, M. D. Morris, J. F. Holson, Computer simulation of mirex pharmacokinetics in the rat. Toxicology and Applied Pharmacology 66, 182-192 (1982).
J. Buelke-Sam, C. A. Kimmel, J. Adams, C. J. Nelson, C. V. Vorhees, D. C. Wright, V. St. Omer, B. A. Korol, R. E. Butcher, M. A. Geyer, J. F. Holson, C. L. Kutscher, M. J. Wayner, Collaborative behavioral teratology study: results. Neurobehavioral Toxicology and Teratology 7, 591-624 (1985).
M. D. Nemec, J. F. Holson, E. J. Tasker, K. D. Oberholtzer, J. F. Knapp, A. Tomiyama, T. Shimada, M. Matsumoto, Assessment of the effect of the anti-ulcer agent, azuletil sodium (KT1-32) on reproduction and prenatal development in Sprague-Dawley Crl: CD BR rats. Yakuri To Chiryo / Japanese Pharmacology and Therapeutics 19, 129-145 (1991).
J. F. Holson, T. B. Gaines, C. J. Nelson, J. B. LaBorde, D. W. Gaylor, D. M. Sheehan, J. F. Young, Developmental toxicity of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T): I. Multireplicated dose-response studies in four inbred strains and one outbred stock of mice. Fundamental and Applied Toxicology 19, 286-297 (1992).
C. J. Nelson, J. F. Holson, T. B. Gaines, J. B. LaBorde, W. F. McCallum, G. L. Wolff, D. M. Sheehan, J. F. Young, Developmental toxicity of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T): II. Multireplicated dose-response studies with technical and analytical grades of 2,4,5-T in four-way outcross mice. Fundamental and Applied Toxicology 19, 298-306 (1992).
B. L. Finley, E. M. Johnson, J. F. Holson, Comment on “comparative effects of trivalent and hexavalent chromium on spermatogenesis of the mouse”. Toxicological & Environmental Chemistry 39, 133-137 (1993).
J. M. DeSesso, C. A. Kimmel, G. L. Kimmel, J. F. Holson, R. G. Skalko, S. B. Harris, A. G. Hendrickx, W. J. Scott, On the subject of incorrect terminology. International Journal of Toxicology 13, 321-323 (1994).
W. F. Heydens, J. C. Siglin, J. F. Holson, S. D. Stegeman, Subchronic, developmental, and genetic toxicology studies with the ethane sulfonate metabolite of alachlor. Toxicological Sciences 33, 173-181 (1996).
J. M. DeSesso, C. F. Jacobson, A. R. Scialli, C. H. Farr, J. F. Holson, An assessment of the developmental toxicity of inorganic arsenic. Reproductive Toxicology 12, 385-433 (1998).
C. S. Elangbam, K. J. Clevidence, C. B. Jackson, J. F. Holson, A communicating intestinal duplication in a Sprague-Dawley rat. Toxicologic Pathology 26, 290-293 (1998).
M. D. Nemec, J. F. Holson, C. H. Farr, R. D. Hood, Developmental toxicity assessment of arsenic acid in mice and rabbits. Reproductive Toxicology 12, 647-658 (1998).
J. Schardein, D. G. Stump, M. Edwards, J. F. Holson, Developmental parameters as assessed in embryo-fetal studies in CD(SD)IGS rats compared to CD(SD) rats. Biological Reference Data on CD(SD)IGS Rats – 1999. (CD(SD)IGS Study Group, Charles River Japan, Inc., 1998), pp. 214-216.
J. M. DeSesso, A. R. Scialli, J. F. Holson, Apparent lability of neural tube closure in laboratory animals and humans. American Journal of Medical Genetics 87, 143-162 (1999).
R. H. Gallavan, J. F. Holson, D. G. Stump, J. F. Knapp, V. L. Reynolds, Interpreting the toxicologic significance of alterations in anogenital distance: potential for confounding effects of progeny body weights. Reproductive Toxicology 13, 383-390 (1999).
J. F. Holson, D. G. Stump, C. E. Ulrich, C. H. Farr, Absence of prenatal developmental toxicity from inhaled arsenic trioxide in rats. Toxicological Sciences 51, 87-97 (1999).
J. F. Holson, J. M. DeSesso, A. R. Scialli, C. H. Farr, Inorganic arsenic and prenatal development: a comprehensive evaluation for human risk assessment. Arsenic Exposure and Health Effects III: Proceedings of the Third International Conference on Arsenic Exposure and Health Effects. (Elsevier Science Ltd, Oxford, 1999), pp. 183-190.
C. F. Jacobson, D. G. Stump, M. D. Nemec, J. F. Holson, J. M. DeSesso, Appropriate exposure routes and doses in studies designed to assess developmental toxicity: a case study of inorganic arsenic. International Journal of Toxicology 18, 361-368 (1999).
D. G. Stump, J. F. Holson, T. L. Fleeman, M. D. Nemec, C. H. Farr, Comparative effects of single intraperitoneal or oral doses of sodium arsenate or arsenic trioxide during in utero development. Teratology 60, 283-291 (1999).
J. F. Holson, D. G. Stump, K. J. Clevidence, J. F. Knapp, C. H. Farr, Evaluation of the prenatal developmental toxicity of orally administered arsenic trioxide in rats. Food and Chemical Toxicology 38, 459-466 (2000).
J. F. Holson, J. M. Desesso, C. F. Jacobson, C. H. Farr, Appropriate use of animal models in the assessment of risk during prenatal development: an illustration using inorganic arsenic. Teratology 62, 51-71 (2000).
C. H. Farr, K. Reinisch, J. F. Holson, D. Neubert, Potential teratogenicity of di‐n‐butyltin dichloride and other dibutyltin compounds. Teratogenesis, Carcinogenesis, and Mutagenesis 21, 405-415 (2001).
B. G. Hammond, D. A. Mayhew, J. F. Holson, M. D. Nemec, R. W. Mast, W. J. Sander, Safety assessment of DHA-rich microalgae from Schizochytrium sp.: II. Developmental toxicity evaluation in rats and rabbits. Regulatory Toxicology and Pharmacology 33, 205-217 (2001).
L. M. Sweeney, T. R. Tyler, C. R. Kirman, R. A. Corley, R. H. Reitz, D. J. Paustenbach, J. F. Holson, M. D. Whorton, K. M. Thompson, M. L. Gargas, Proposed occupational exposure limits for select ethylene glycol ethers using PBPK models and Monte Carlo simulations. Toxicological Sciences 62, 124-139 (2001).
B. D. Beck, T. M. Slayton, C. H. Farr, D. W. Sved, E. A. Crecelius, J. F. Holson, Systemic uptake of inhaled arsenic in rabbits. Human & Experimental Toxicology 21, 205-215 (2002).
L. A. Burns-Naas, D. G. Stump, S. Webber, J. F. Holson, L. Masarjian, G. Furman, M. Zorbas, Absence of reproductive and developmental toxicity in rats following oral dosing with nelfinavir. Regulatory Toxicology and Pharmacology 38, 304-316 (2003).
L. A. Burns-Naas, S. Webber, D. G. Stump, J. F. Holson, L. Masarjian, M. Zorbas, Absence of embryo-fetal toxicity in rats or rabbits following oral dosing with nelfinavir. Regulatory Toxicology and Pharmacology 38, 291-303 (2003).
R. N. Hines, J. Adams, G. M. Buck, W. Faber, J. F. Holson, S. W. Jacobson, M. Keszler, K. McMartin, R. T. Segraves, L. T. Singer, NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of fluoxetine. Birth Defects Research. Part B, Developmental and Reproductive Toxicology 71, 193-280 (2004).
G. Kimmel, S. Harris, M. Tassinari, T. Knudsen, H. Cunny, R. Tyl, B. Carlton, J. Holson, W. Slikker, Concern over decreased training in embryology and developmental/reproductive toxicology. Birth Defects Research. Part B, Developmental and Reproductive Toxicology 71, 191-192 (2004).
G. Kimmel, S. Harris, M. Tassinari, T. Knudsen, H. Cunny, R. Tyl, B. Carlton, J. Holson, W. Slikker, Commentary. Reproductive Toxicology 18, 623-624 (2004).
A. E. Mitchell, K. S. Bakshi, C. A. Kimmel, G. M. Buck, M. H. Feuston, P. M. D. Foster, J. M. Friedman, J. F. Holson, C. L. Hughes, J. A. Moore, B. A. Schwetz, A. R. Scialli, W. J. Scott, C. V. Vorhees, B. R. Zirkin, Evaluating chemical and other agent exposures for reproductive and developmental toxicity. Journal of Toxicology and Environmental Health, Part A 67, 1159-1314 (2004).
J. F. Holson, D. G. Stump, L. B. Pearce, R. E. Watson, J. M. DeSesso, Mode of action: yolk sac poisoning and impeded histiotrophic nutrition–HBOC-related congenital malformations. Critical Reviews in Toxicology 35, 739-745 (2005).
J. Doull, J. F. Borzelleca, R. Becker, G. Daston, J. DeSesso, A. Fan, P. Fenner-Crisp, M. Holsapple, J. Holson, G. Craig Llewellyn, Framework for use of toxicity screening tools in context-based decision-making. Food and Chemical Toxicology 45, 759-796 (2007).
R. G. Meeks, D. G. Stump, W. H. Siddiqui, J. F. Holson, K. P. Plotzke, V. L. Reynolds, An inhalation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats using multiple and single day exposure regimens. Reproductive Toxicology 23, 192-201 (2007).
W. H. Siddiqui, D. G. Stump, K. P. Plotzke, J. F. Holson, R. G. Meeks, A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation. Reproductive Toxicology 23, 202-215 (2007).
W. H. Siddiqui, D. G. Stump, V. L. Reynolds, K. P. Plotzke, J. F. Holson, R. G. Meeks, A two-generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reproductive Toxicology 23, 216-225 (2007).
D. G. Stump, J. F. Holson, S. R. Murphy, C. H. Farr, B. Schmit, M. Shinohara, An oral two-generation reproductive toxicity study of S-111-S-WB in rats. Reproductive Toxicology 25, 7-20 (2008).
M. Nemec, E. Sloter, D. Stump, J. Holson, D. Kirkpatrick, J. Kinzell, Prenatal developmental toxicity studies of inhaled methyl iodide vapor in rabbits reveal a susceptible window of exposure inducing late gestational fetotoxicity. Inhalation Toxicology 21, 449-461 (2009).
E. Sloter, M. Nemec, D. Stump, J. Holson, D. Kirkpatrick, M. Gargas, J. Kinzell, Methyl iodide-induced fetal hypothyroidism implicated in late-stage fetal death in rabbits. Inhalation Toxicology 21, 462-479 (2009).
V. L. Reynolds, D. G. Stump, J. F. Holson, Assessing the toxicological significance of ejaculatory plugs as a clinical observation in rat toxicology studies: CNS-mediated increases in plug production vs. gustatory-mediated decreases in plug consumption. Reproductive Toxicology 29, 271-278 (2010).
J.F. Holson, D.G. Stump, L.B. Pearce, R.E. Watson, J.M. DeSesso, Absence of developmental toxicity in a canine model after infusion of a hemoglobin-based oxygen carrier: implications for risk assessment. Reproductive Toxicology 52, 101-107 (2015).
Abstracts
J. F. Holson, E. C. Simpson, Teratogenic potential of LSD in the albino rat. The Journal of the Elisha Mitchell Scientific Society 85, 4 (1969).
J. F. Holson, J. G. Wilson, Yolk sac exteriorization: a procedure for quantitative assessment of yolk sac transport during early organogenesis in rats. Teratology 7, A17 (1973).
J. F. Holson, T. B. Gaines, H. J. Schumacher, C. J. Nelson, D. W. Gaylor, Teratogenic evaluation of food coloring agent Red Dye 2 administered orally to rats. Teratology 9, A20-A21 (1974).
J. F. Holson, J. G. Wilson, Changing placental roles of rodent chorioallantoic and yolk sac placentae during organogenesis. Teratology 9, A21 (1974).
J. F. Holson, J. F. Young, Importance of experimental design in studying relationships between placental transfer and teratogenesis. Teratology 11, A22 (1974).
T. B. Gaines, J. F. Holson, C. J. Nelson, H. J. Schumacher, Analysis of strain differences in sensitivity and reproducibility of results in assessing 2,4,5-T teratogenicity in mice. Toxicology and Applied Pharmacology 33, 130 (1975).
J. F. Holson, T. B. Gaines, H. J. Schumacher, M. F. Cranmer, Is red dye #2 teratogenic: a joint government-industry approach to a toxicological problem. Toxicology and Applied Pharmacology 33, 1 (1975).
J. Buelke-Sam, J. F. Holson, Dynamics of uterine blood flow during organogenesis in the rat. Teratology 19, A21 (1979).
R. A. Byrd, J. F. Holson, C. A. Kimmel, M. D. Morris, J. F. Young, Altered spectrum of embryotoxic effects in rats due to different treatment schedules with mirex. Teratology 19, A22 (1979).
J. F. Holson, C. J. Nelson, H. J. Schumacher, Comparison of dihybrid, inbred, and outbred animals for use in teratological testing studies. Journal of Toxicology and Environmental Health 5, 144 (1979).
J. T. McVey, J. Hunziker, J. F. Holson, J. F. Young, Small animal whole body gamma counter – multiple adaptations and evaluations. Health Physics 37, 823 (1979).
C. G. White, J. F. Holson, J. F. Young, Pharmacokinetic basis for the development and use of mathematical models in teratogenesis. Teratology 19, A53 (1979).
J. F. Young, C. A. Kimmel, J. F. Holson, Validation of a pharmacokinetic model for rat embryonal dosimetry of salicylates during a teratogenically susceptible period. Toxicology and Applied Pharmacology 48, A121 (1979).
J. Buelke-Sam, J. F. Holson, Distribution of maternal blood flow throughout gestation in the rat. Teratology 21, A31 (1980).
R. A. Byrd, J. F. Holson, C. A. Kimmel, M. D. Morris, J. F. Young, Computer simulations of 14C-mirex pharmacokinetics in female CRL:COBS CD(SD) BR rats. Toxicology and Applied Pharmacology 53, (1980).
R. A. Byrd, J. F. Holson, M. D. Morris, Mirex-induced changes in maternal hemodynamics on gestation day 16 in rats. Teratology 21, 33A (1980).
J. F. Holson, Estimation and extrapolation of teratologic risk. Proceedings of a NATO Advanced Research Institute on “In Vitro Toxicity Testing of Environmental Agents: Current and Future Possibilities,” Plenum Press, New York, 1980.
J. F. Holson, C. A. Kimmel, J. F. Young, The precision of pharmacokinetic parameters for predicting embryotoxicity endpoints. Toxicology and Applied Pharmacology 53, (1980).
C. G. White, J. F. Holson, Examination of dose-response relationships in reproductive toxicology. Teratology 21, A75 (1980).
C. G. White, J. F. Young, J. F. Holson, Pharmacokinetic approach to analysis of the “window” effect in teratologic sensitivity. Toxicology and Applied Pharmacology 53, (1980).
W. R. Campbell, S. B. Harris, J. F. Holson, A teratogenic evaluation of Diazinon® with rabbit. The Toxicologist 2, 120 (1982).
H. A. Birhbaum, S. B. Harris, J. F. Holson, S. K. Keener, Teratological evaluation of methyldibromoglutaronitrile in rats. Toxicology Letters 18, 158 (1983).
J. F. Holson, Toxicology related to halon alternatives. Conference Proceedings, International CFC and Halon Alternatives Conference. (Baltimore, MD, 1991).
M. D. Nemec, J. F. Holson, D. Naas, J. Knapp, I. Lamb, D. McAllister, The developmental toxicity of FM-100® in the rat and rabbit following repeated exposure by inhalation. Teratology 45, 475 (1992).
M. D. Nemec, J. F. Holson, D. Naas, K. Oberholtzer, B. Varsho, D. McAllister, The single-day-exposure inhalation developmental toxicity studies of FM-100® in the rat. Teratology 45, 501 (1992).
J. F. Holson, M. Nemec, E. Craine, R. Dahlgren, D. Naas, I. Lamb, A model for academic-industry cooperation in undergraduate education in toxicology. The Toxicologist 13, 244 (1993).
M. D. Nemec, G. T. Arce, J. F. Holson, V. J. Piccirillo, Assessment of the effect of orally administered maneb technical on prenatal development in the rat. Teratology 47, 430 (1993).
M. D. Nemec, J. F. Holson, D. J. Naas, M. H. Shour, J. M. Gerhart, An assessment of reproduction in female rats exposed to carbon disulfide (CS2) vapor. Teratology 47, 430 (1993).
M. Nemec, J. F. Holson, D. Naas, J. Knapp, I. Lamb, J. Biesemeier, An assessment of the potential developmental toxicity of heptafluoropropane (FM-200®) by inhalation in the rat. Teratology 49, 420 (1994).
J. M. DeSesso, I. J. Boyer, J. F. Holson, Evaluation of developmental toxicology studies of chloroform. An Evaluation of EPA’s Proposed Guidelines for Carcinogen Risk Assessment Using Chloroform and Dichloroacetate as Case Studies: Report of an Expert Panel. (International Life Sciences Institute, Washington, DC, 1997), pp. 10.
T. L. Fleeman, D. G. Stump, K. J. Clevidence, M. D. Nemec, J. F. Holson, Validation of computer-assisted sperm analysis for motility and concentration in the rabbit. The Toxicologist 36, 357 (1997).
R. W. Mast, J. F. Holson, D. G. Stump, V. L. Reynolds, Inhalation reproductive toxicity study of octamethycyclotetrasiloxane (D4) in female rats. The Toxicologist 36, 357 (1997).
D. G. Stump, M. D. Nemec, J. F. Holson, V. J. Piccirillo, J. T. Mares, Study of the effects of sulfluramid on pre- and postnatal development, maturation and fertility in the rabbit. The Toxicologist 36, 357 (1997).
J. M. DeSesso, C. F. Jacobson, A. R. Scialli, C. H. Farr, J. F. Holson, Inorganic arsenic is not likely to be a developmental toxicant at environmentally relevant exposures. Teratology 57, 216 (1998).
C. S. Elangbam, C. P. Chengelis, G. R. Kiplinger, D. J. Naas, J. F. Holson, J. L. Schardein, J. J. W. Mertens, C. B. Jackson, L. Myers, L. Watson, 1,4-dichlorobenzene-induced renal epithelial proliferation: anti-bromodeoxyuridine and anti-proliferating nuclear cell antigen immunohistochemical and histopathologic evaluations. Toxicologic Pathology 26, 166-167 (1998).
R. H. Gallavan, J. F. Holson, J. F. Knapp, V. L. Reynolds, D. G. Stump, Anogenital distance: potential for confounding effects of progeny body weights on interpreting toxicologic significance. Teratology 57, 245 (1998).
R. D. Hood, M. D. Nemec, J. F. Holson, C. H. Farr, Effects of mid-gestational exposure of mice and rabbits to arsenic acid. The Toxicologist 42, 258 (1998).
V. L. Reynolds, J. M. DeSesso, R. W. Mast, D. G. Stump, J. F. Holson, Reproductive toxicity studies with octamethylcyclotetrasiloxane in female rats using various exposure regimens. Toxicology Letters 95, 216 (1998).
D. G. Stump, K. J. Clevidence, J. F. Knapp, J. F. Holson, C. H. Farr, An oral developmental toxicity study of arsenic trioxide in rats. Teratology 57, 216 (1998).
D. G. Stump, T. L. Fleeman, M. D. Nemec, J. F. Holson, C. H. Farr, Evaluation of the teratogenicity of sodium arsenate and arsenic trioxide following single oral or intraperitoneal administration in rats. Teratology 57, 217 (1998).
D. G. Stump, C. E. Ulrich, J. F. Holson, C. H. Farr, An inhalation developmental toxicity study of arsenic trioxide in rats. Teratology 57, 216 (1998).
J. A. Pitt, L. T. Snyder, B. L. Smith, B. J. Varsho, M. D. Nemec, J. F. Holson, An x-ray study of the incidence of supernumerary ribs and presacral vertebrae in adult rats, mice and rabbits. Teratology 65, 328 (2002).
M. J. Beck, D. G. Stump, M. D. Nemec, J. F. Holson, J. P. Tizzano, J. Buelke-Sam, Developmental toxicity studies in rats and rabbits with DOV 21,947: A triple reuptake inhibitor. Birth Defects Research. Part B, Developmental and Reproductive Toxicology 68, 231 (2003).
J. M. DeSesso, J. F. Holson, An analysis and review of the relative morphology of extraembryonic membranes in mammals and their roles in histiotrophic nutrition and as possible sites of developmental insult. Birth Defects Research. Part A, Clinical and Molecular Teratology 67, 346 (2003).
J. F. Holson, L. B. Pearce, D. G. Stump, A probable false positive finding of prenatal toxicity in the rodent model with a high molecular weight protein oxygen therapeutic: evidence and implications. Birth Defects Research. Part B, Developmental and Reproductive Toxicology 68, (2003).
J. F. Knapp, D. G. Stump, B. J. Varsho, M. D. Nemec, J. F. Holson, C. P. Chengelis, Validation of the Hershberger assay in peripubertal orchidoepididyectomized rats. Journal of Toxicological Sciences 28, 366 (2003).
G. J. Schaefer, D. T. Kirkpatrick, J. F. Holson, C. P. Chengelis, K. S. Regan, V. J. Piccirillo, A six-week inhalation neurotoxicity study of methyl bromide in dogs. Toxicological Sciences 72, 304 (2003).
M. J. Beck, M. D. Nemec, D. Kirkpatrick, J. F. Holson, S. A. Lewis, V. J. Piccirillo, D. McAllister, A method for simultaneous whole-body inhalational (inh.) exposure of lactating rats and offspring. Birth Defects Research. Part A, Clinical and Molecular Teratology 73, 5 (2005).
J. F. Holson, R. D. Hood, D. G. Stump, J. M. Rogers, S. L. Makris, Developmental toxicology studies: design, interpretation and risk assessment. The Toxicologist 84, 1 (2005).
M. D. Nemec, E. D. Sloter, J. F. Holson, D. G. Stump, J. Kinzell, Prenatal developmental toxicity studies in rabbits reveal a susceptible window of methyl iodide-induced fetotoxicity late in gestation. The Toxicologist 84, 50 (2005).
E. D. Sloter, M. D. Nemec, R. Baumgartner, J. F. Holson, M. Gargas, J. Kinzell, Methyl iodide-induced hypothyroidism in fetal rabbits. The Toxicologist 84, 50 (2005).
B. J. Varsho, D. G. Stump, J. F. Holson, K. J. Clevidence, C. A. Kopp, J. M. Nussbaum, M. D. Nemec, A comparison of reproductive parameters between artificially inseminated and naturally mated Hra:(NZW)SPF rabbits. Birth Defects Research. Part A, Clinical and Molecular Teratology 73, 354 (2005).
M. J. Beck, D. A. Donahue, J. S. Varsho, M. D. Nemec, D. G. Stump, J. F. Holson, The effects of methimazole on circulating thyroid hormone levels in Sprague-Dawley rats. Birth Defects Research. Part A, Clinical and Molecular Teratology 76, 328 (2006).
M. J. Beck, H. Fillutzy, J. Godsey, M. D. Nemec, D. G. Stump, J. F. Holson, The ontogeny of circulating thyroid hormone levels in Sprague-Dawley rats. Birth Defects Research. Part A, Clinical and Molecular Teratology 76, 327 (2006).
W. H. Siddiqui, D. G. Stump, J. F. Holson, D. T. Kirkpatrick, K. P. Plotzke, An inhalation F1 generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats. The Toxicologist 90, 253 (2006).
B. J. Varsho, M. D. Nemec, D. G. Stump, P. A. Birchmeier, J. E. Howell, J. F. Holson, A comparison of fetal malformation and developmental variation rates of artificially inseminated vs. naturally mated Hra:(NZW) SPF rabbits. Birth Defects Research. Part A, Clinical and Molecular Teratology 76, 388 (2006).
P. Sawhney, P. A. Birchmeier, B. J. Varsho, D. G. Stump, M. D. Nemec, J. F. Holson, A comparison of maternal growth curves and reproductive parameters between HR-A:(NZW) SPF rabbits obtained from the Denver or Kalamazoo facilities of covance research products. Birth Defects Research. Part A, Clinical and Molecular Teratology 79, 415 (2007).
D. G. Stump, J. F. Holson, S. R. Murphy, C. H. Farr, B. Schmit, M. Shinohara, An oral two-generation reproductive toxicity study of S-111-S-WB in rats. The Toxicologist 96, 426 (2007).
M. J. Beck, M. D. Nemec, D. G. Stump, J. F. Holson, Design considerations and implications for neurobehavioral data. The Toxicologist 102, 355 (2008).
C. Roegge, A. Evans, M. Beck, P. Atterson, D. Stump, M. Nemec, J. Holson, Comparison of training procedures for self-administration of cocaine in female rats. Neurotoxicology and Teratology 30, 255 (2008).
P. Sawhney Coder, R. M. Barrett, B. J. Varsho, D. G. Stump, M. D. Nemec, J. F. Holson, Comparison of fetal malformation and developmental variation rates between Hra:(NZW) SPF rabbits obtained from the Denver or Kalamazoo facilities of Covance Research Products. Birth Defects Research. Part A, Clinical and Molecular Teratology 82, 353 (2008).
E. D. Sloter, M. Nemec, D. Stump, S. Pritt, M. Beck, T. Gleason, W. Miller, J. Holson, Ambulatory continuous intravenous infusion model for pregnant Dutch Belted rabbits. The Toxicologist 102, 474 (2008).
