The following are invited scientific presentations that I have given in a variety of settings throughout my professional career in toxicology.
J. F. Holson, Teratogenic Potential of LSD in the Albino Rat. Presented to the North Carolina Academy of Sciences, Wilmington, NC, May 1969.
J. F. Holson, Yolk Sac Exteriorization: A Procedure for Quantitative Assessment of Yolk Sac Transport During Early Organogenesis in Rats. Presented at the Thirteenth Annual Meeting of the Teratology Society, St. Jovite, Quebec, Canada, June 13-16, 1973.
J. F. Holson, Changing Placental Roles of the Rodent Chorioallantoic and Yolk Sac Placentae During Organogenesis. Presented at the Fourteenth Annual Meeting of the Teratology Society, Vancouver, British Columbia, Canada, July 7-10, 1974.
J. F. Holson, Is Red Dye #2 Teratogenic? A Joint Government-Industry Approach to a Toxicological Problem. Presented at the Fourteenth Annual Meeting of the Society of Toxicology, Williamsburg, Virginia, March 9–13, 1975.
J. F. Holson, Importance of Experimental Design in Studying Relationships Between Placental Transfer and Teratogenesis. Presented at the Symposium of Preclinical Testing for Teratogenicity, Fifteenth Annual Meeting of the Teratology Society, Pocono Manor, Pennsylvania, May 11–14, 1975.
J. F. Holson, Interpretation of Teratological Data: The Industrial-Regulatory Interface. Presented at the Annual Summer Meeting of the Toxicology Forum, Aspen, CO, August 1976.
J. F. Holson, Research Programs in Teratology at the National Center for Toxicological Research. Presented to the Developmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, February 1977.
J. F. Holson, Current Problems in Toxicological Evaluation of Food Additives and Environmental Chemicals. Presented as part of the Sigma Xi Lecture Series, East Carolina University, Greenville, NC, February 1977.
J. F. Holson, Comparison of Dihybrid, Inbred and Outbred Animals for Use in Teratologic Testing Studies. Presented at the First Annual NCTR-NCI Symposium-Workshop on “The Use of Inbred and Outbred Animals in Toxicologic Testing,” Little Rock, AR, February 1978.
J. F. Holson, Estimation and Extrapolation of Teratologic Risk. Presented at the NATO Advanced Research Institute on “In Vitro Toxicity Testing of Environmental Agents: Current and Future Possibilities”, Monte Carlo, Monaco, September 22-28, 1979.
J. F. Young, J. F. Holson, C. A. Kimmel, Utilization of Pharmacokinetic Principles in Extrapolation from Animal Data to Man. Presented at the 39th International Congress of Pharmaceutical Sciences, Brighton, England, September, 1979.
J.F. Holson, The Precision of Pharmacokinetic Parameters for Predicting Embryotoxicity Endpoints. Presented at the Nineteenth Annual Meeting of the Society of Toxicology, Washington, DC, March 9–13, 1980.
J.F. Holson, Pharmacokinetic Approach to Analysis of the “Window” Effect in Teratologic Sensitivity. Presented at the Nineteenth Annual Meeting of the Society of Toxicology, Washington, DC, March 9–13, 1980.
J.F. Holson, Extrapolation of Embryotoxicity Data from Animals to Man. Presented at Syntex Co., Palo Alto, CA, April 1980.
J.F. Holson, Interpretation of Data from Animal Models in Teratology. Presented at the U.S. Food and Drug Administration, Washington, DC, May 1980.
J.F. Holson, Predictability of Animal Models in Teratogenesis. Presented at the Third International Caffeine Workshop, Hunt Valley, MD, October 27-29, 1980.
J.F. Holson, C. A. Kimmel, C. Hogue, G. Carlo, Suitability of Experimental Studies for Predicting Hazards to Human Development. Presented at the Annual Winter Meeting of the Toxicology Forum, Arlington, VA, February 16-18, 1981.
J.F. Holson, Toxicology Related to Halon Alternatives. Presented at the International CFC and Halon Alternatives Conference, Baltimore, MD, December 3-5, 1991.
J.F. Holson, Significance of Anatomic Deviations in Predicting Toxicologic Risks to Prenatal Development – Human and Experimental Studies. Discussion group organizer and presenter, The Teratology Society Thirty-First Annual Meeting, Boca Raton, FL, June 22-27, 1991.
J. M. DeSesso, J. F. Holson, Specialized Terminology, the Analysis of Results, and Report Preparation for Developmental and Reproductive Toxicology Tests. Course presented at the FDA Center for Drug Evaluation and Research on Special Topics in Reproductive Toxicology and the New ICH Guidelines, November 16, 1995; April 1, 1996; October 24, 1996.
J. M. DeSesso, J. F. Holson, General Principles Underlying the Science and Testing Procedures for Developmental and Reproductive Toxicology. Course presented at the FDA Center for Drug Evaluation and Research on Special Topics in Reproductive Toxicology and the New ICH Guidelines, November 9, 1995; March 25, 1996; October 17, 1996.
J. F. Holson, J. M. DeSesso, Developmental and Reproductive Toxicology Study Interpretation. Course presented at the FDA Center for Drug Evaluation and Research on Special Topics in Reproductive Toxicology and the New ICH Guidelines, December 7, 1995; April 29, 1996; November 7, 1996.
J. F. Holson, J. M. DeSesso, Animal Studies and the Prediction of Human Reproductive Risk: Case Studies of Success and Failure. Course presented at the FDA Center for Drug Evaluation and Research course on Special Topics in Reproductive Toxicology and the New ICH Guidelines, November 2, 1995; April 15, 1996; October 10, 1996.
J. M. DeSesso, J. F. Holson, Physiologically Based Pharmacokinetics in Pregnant Mammals and Their Embryos: Concepts for Understanding and Appropriate Application to Human Health Risk Assessment. Continuing education course presented at the Eighteenth Annual Meeting of the American College of Toxicology, McLean, VA, November 9, 1997.
J. F. Holson, Basis of Understanding Risk: Do We Really Understand It? Presented at the Ninth North American International Symposium of the International Society of Quality Assurance, Orlando, FL, March 23-25, 1998.
J. F. Holson, J. M. DeSesso, A. R. Scialli, C. H. Farr, Inorganic Arsenic and Prenatal Development: A Comprehensive Evaluation for Human Risk Assessment. Presented at the Third International Conference on Health Effects of Environmental Arsenic, Society of Environmental Geochemistry and Health, San Diego, CA, July 12-15, 1998.
J. F. Holson, J. M. DeSesso, Application of Appropriate Exposure Routes and Dose to Human Risk Assessment: A Case Study of Inorganic Arsenic and Prenatal Development. Presented at the American College of Toxicology Annual Meeting, Orlando, FL, November 11, 1998.
J. F. Holson, J. M. DeSesso, Postnatal Development in Experimental Animals and Man: Implications for the Assessment of Health Safety Data. Presented at the Annual Winter Meeting of the Toxicology Forum, Washington, DC, February 3, 1999.
J.F. Holson, Safety Assessments in Pediatric Populations. Course lecture given to the Southern California Regional Chapter of the Society of Toxicology, Newport Beach, CA, June 3, 1999.
J.F. Holson, Overview: Aspects of Postnatal Growth; Ontogeny of Organ Systems. Presented in continuing education course (“Organ System Maturation and Functional Postnatal Development”) at the Thirty-Ninth Annual Meeting of the Teratology Society, Keystone, CO, June 29 – July 3, 1999.
J.F. Holson, Reproductive Toxicology – What Do the Regulators Want? Presented at the Henry Stewart Conference: Understanding the Regulators’ Approach to Reproductive Toxicology Data, Washington, DC, April 18-19, 2000.
J.F. Holson, Points to Consider, Presented to the Pediatric Advisory Council, Sepracor, Inc., Marlborough, MA, 2000.
J.F. Holson, Reproductive Toxicology – What Do the Regulators Want? Presented at Lilly Research Laboratories, Greenfield, IN, February 23, 2001.
J. F. Holson, Reproductive Toxicology – What Do the Regulators Want? Presented at the Henry Stewart Conference: Understanding the Regulators’ Approach to Reproductive Toxicology Data, Washington, DC, April 26-27, 2001.
J.F. Holson, Postnatal Evaluation in Developmental and Juvenile Toxicity Studies. Presented at the Twenty-Eighth Annual Meeting of the Japanese Society of Toxicology, Tokyo, Japan, June 10-12, 2001.
J.F. Holson, Regulatory and Scientific Impact of FDAMA. Presented at ALZA Corporation, Mountain View, CA, 2001.
J.F. Holson, Forward Thinking or Reverse Logic? Novel Strategies for Developmental Toxicology (MTA/MARTA Title: Overview of In Vitro Strategies for Developmental Toxicity Screening and Problem Solving). Presented at the Midwest Teratology Association (MTA) and Middle Atlantic Reproductive and Teratology Association (MARTA) Annual Meeting, Split Rock Resort & Golf Club, Lake Harmony, PA, 2001.
J.F. Holson, Ontogeny of Physiologic Regulations and Models of Juvenile Toxicology. Presented as part of “Ontogeny, Safety Assessment Testing and the Paediatrician” at the Developmental Pathology Society Annual Meeting, hosted by GlaxoSmithKline Research & Development, Ware, United Kingdom, October 17, 2001.
J.F. Holson, Interpretation of Low Incidence Findings in Reproductive and Developmental Toxicity Studies. Presented at the Annual Winter Meeting of the Toxicology Forum, Washington, DC, February 4-6, 2002.
J. F. Holson, Reproductive Toxicology – What Do the Regulators Want? Presented at the Henry Stewart Conference: Meeting FDA, EPA, OECD and ICH Requirements for Reproductive Toxicology Data Submissions, Washington, DC, May 9-10, 2002.
J.F. Holson, Mechanisms, Biomarkers, Data Interpretation: An Integrative Risk Assessment using Developmental Neurotoxicity as a Model. Facilitator for panel discussion that concluded this continuing education course at the Forty-Second Annual Meeting of the Teratology Society, Scottsdale, AZ, June 22-27, 2002.
J.F. Holson, Screening Tests for Toxic Chemicals: An Overview. Presented at the International Life Sciences Institute (ILSI), Washington, DC, October 8, 2002.
J.F. Holson, Reproductive Toxicology: History and State of Regulatory Science. Presented at CTE/CDER, Food and Drug Administration, Washington, DC, October 17, 2002.
J.F. Holson, Features of Safety Assessment Studies to be Considered in Assessing Thyroid Effects of Reproduction and Their Relevance to Human Health. Presented at the NTP-CERHR Workshop on Thyroid Toxicants: Assessing Reproductive Health Effects, Alexandria, VA, April 28-29, 2003.
J. F. Holson, Reproductive Toxicology – What Do the Regulators Want? Presented at the Henry Stewart Conference: Latest Thinking on Reproductive, Developmental, and Endocrine Toxicity Studies, Washington, DC, May 21-22, 2003.
J.F. Holson, Overview of Issues Concerning False Positive Findings in Reproductive Toxicology and Introduction of a Case Study of an Oxygen Therapeutic. Presented in Symposium I (“A Detective Story: Is the Prenatal Toxicity of a Therapeutic in Rats Relevant to Human Risk?”, J.F. Holson and L. B. Pearce, co-chairpersons) at the Forty-Third Annual Meeting of the Teratology Society, Philadelphia, PA, June 26, 2003.
D. G. Stump, J.F. Holson, Finding of Developmental Toxicity Studies of HBOC–201 in Rodent and Canine Models. Presented in Symposium I (“A Detective Story: Is the Prenatal Toxicity of a Therapeutic in Rats Relevant to Human Risk?”, J.F. Holson and L. B. Pearce, co-chairpersons) at the Forty-Third Annual Meeting of the Teratology Society, Philadelphia, PA, June 26, 2003.
J. DeSesso, J.F. Holson, An Analysis and Review of the Relative Morphology of Extraembryonic Membranes in Mammals and Their Roles in Histiotrophic Nutrition and as Possible Sites of Development Insult. Presented in Symposium I (“A Detective Story: Is the Prenatal Toxicity of a Therapeutic in Rats Relevant to Human Risk?”, J.F. Holson and L. B. Pearce, co-chairpersons) at the Forty-Third Annual Meeting of the Teratology Society, Philadelphia, PA, June 26, 2003.
J. M. DeSesso, P. M. D. Foster, J. F. Holson, Applied Reproductive Toxicology. Presented at the Pest Management Regulatory Agency, Health Canada, Ottawa, Ontario, October 6-7, 2003.
J.F. Holson, Overview of Preclinical Development and Reproductive Studies. Presented for the Midwest Teratology Association, Pfizer Global Research and Development, Ann Arbor, MI, 2004.
J.F. Holson, Human Clinical Relevance of Developmental and Reproductive Toxicology and Nonclinical Juvenile Testing. Presented at Forest Research Institute, Inc., Jersey City, NJ, May 13, 2004.
J.F. Holson, Reproductive Toxicology – What Do the Regulators Want? Presented at the Henry Stewart Annual Briefing on Current Thinking, Problems and Solutions in Reproductive, Developmental, and Endocrine Toxicity Studies, Washington, DC, June 16-17, 2004.
J.F. Holson, Study Design Considerations Affecting Interpretation of Developmental Toxicity Data (Program Title: Overview of Developmental Toxicity Study Designs, Endpoints Sensitivities, Statistical Power, Variability, and Use of Historical Control Data). Presented in continuing education course (“Developmental Toxicology Studies: Design, Interpretation, and Risk Assessment, J.F. Holson and R. D. Hood, co-chairpersons) at the Forty-Fourth Annual Meeting of the Society of Toxicology, New Orleans, LA, March 6-10, 2005.
J.F. Holson, Male Reproductive Toxicants: From the Fetus to the Adult. Presented at the Henry Stewart Annual Briefing on Current Thinking, Problems and Solutions in Reproductive, Developmental and Endocrine Toxicity Studies, Washington, DC, May 12-13, 2005.
J.F. Holson, The Pregnant, Unborn and Children as Sensitive Subpopulations Per Se (ACT Title: Use of Segment II and III Reproductive Toxicity Studies for Alternative Endpoints). Presented at the Annual Meeting of the American College of Toxicology, Williamsburg, VA, November 5, 2005.
J.F. Holson, Current Regulatory Requirements in Developmental and Reproductive Toxicity Assessments: Segmental Study Designs vs. the Biologic Continuum. Presented at the Northern California SOT Spring Symposium, SRI International Conference Center, Menlo Park, CA, June 7, 2007.
